Table 1 Cross-sectional and cohort studies on the association between thyroid hormones and chronic kidney disease
From: Interrelationship between thyroid hormones and reduced renal function, a review article
First author(year) | Type of Study | Country | Sample size | Setting | Mean age | Follow-up Time | Result (TSH) | Result (FT4) | Result (FT3) | Result (TPO Ab) |
|---|---|---|---|---|---|---|---|---|---|---|
Layal Chaker (2016) | cohort | Netherlands | 5103 | Population-based study (Rotterdam) | 63.6 | 8.1 years | Negative association with eGFR and CKD incidence(OR = 0.85) | No association | Not assessed | Not assessed |
X. Huang(2016) | cohort | Shanghai | 2103 | Community-based study | 59.3 | 4 years | Not significant | Positive correlation with CKD incidence (OR = 1.88) | Not significant | Not assessed |
Gordon Williams (2021) | cross-sectional | US | 789 | Population-based study | 45.94 | Â | Negative correlation with RPF in euthyroids | Not assessed | Not assessed | Not assessed |
Ulla T. Schultheiss (2017) | cohort | US | 12,785 | Community-based study (ARIC study) | 57.4 | 19.6 years | No association | Positive association with incident CKD | No association | No association |
Peggy Sekula (2020) | cohort | European | 4600 | Population-based study (German chronic kidney disease study) | 60 | 4 years | Not assessed | No association | Negative association with renal events (ESRD, AKI, renal death) | Not assessed |
Yasuji Arase (2019) | cohort | Japan | 7609 | Hospital-based study (Toranomon Hospital in Tokyo) | 54 | 3 years | Higher normal TSH: positive association with incident CKD (OR = 0.86) Above normal TSH: positive association with incident CKD (OR = 1.58) | Not assessed | Not assessed | Not assessed |
Eliseo Guallar (2014) | cohort | South Korean | 104,633 | Population-based study (Kangbuk Samsung Health Study) | 38 | 3.5 years | Positive association with incident CKD ( baseline HR = 1.59, time-varying HR = 1.61) | No association | Negative association with incident CKD (HR = 0.95 ) | Not assessed |
Sijue Yang (2021) | case-control | China | 2831 | Hospital-based study (China Medical University) | 51.08 | Â | Negative correlation with eGFR | Not assessed | Not assessed | Not assessed |
Binbin Pan (2019) | cross-sectional | China | 905 | Hospital-based study | 52.6 | Â | No association | No association | Positive correlation with eGFR | Not assessed |
Keisuke Endo (2023) | cohort | Japan | 10,392 | population-based study | 48 | 10 years | Positive association with incident CKD in TSH levels > 4.2 ( HR = 1.41) in men but not in woman | Not assessed | Not assessed | Not assessed |