Table 1 Integrated dysregulated pathways from PTC-associated human multi-OMICs data
Human_PTC_transcriptomic ∩ Human_PTC _proteomic ∩ Human_PTC _metabolomic | Citrate cycle (TCA cycle) Glyoxylate and dicarboxylate metabolism |
Human_PTC _proteomic ∩ Human_PTC _metabolomic | Alanine aspartate and glutamate metabolism Aminoacyl-tRNA biosynthesis Arginine and proline metabolism Butanoate metabolism Fructose and mannose metabolism Glycine serine and threonine metabolism Glycolysis/Gluconeogenesis Pentose phosphate pathway Phenylalanine metabolism Propanoate metabolism Pyruvate metabolism Synthesis and degradation of ketone bodies Tyrosine metabolism Valine leucine and isoleucine degradation |
Human_PTC_transcriptomic ∩ Human_PTC_metabolomic | Glycerolipid metabolism |
Human_PTC _metabolomic ∩ Human_PTC_SNPs | Inositol phosphate metabolism |
Human_PTC_transcriptomic ∩ Human_PTC _proteomic ∩ Human_PTC_SNPs | Bacterial invasion of epithelial cells Focal adhesion Human papillomavirus infection Necroptosis Nonalcoholic fatty liver disease PI3K-Akt signaling pathway Pathogenic Escherichia coli infection Pathways of neurodegeneration Prion disease Proteoglycans in cancer Small cell lung cancer Yersinia infection |
Human_PTC_transcriptomic ∩ Human_PTC _proteomic | Arrhythmogenic right ventricular cardiomyopathy Diabetic cardiomyopathy ECM-receptor interaction Fc gamma R-mediated phagocytosis Glutathione metabolism Platelet activation Tight junction Viral myocarditis |
Human_PTC_proteomic ∩ Human_PTC_SNPs | Adherens junction African trypanosomiasis Alzheimer disease Amoebiasis Apoptosis Central carbon metabolism in cancer Complement and coagulation cascades Coronavirus disease Estrogen signaling pathway Ferroptosis Fluid shear stress and atherosclerosis HIF-1 signaling pathway Malaria Regulation of actin cytoskeleton Salmonella infection Shigellosis Thermogenesis Thyroid hormone synthesis Viral carcinogenesis |