Are liquid levothyroxine formulations comparable? The LETI study

Table 2 Serum TSH, fT4 levels and LT4 dosage/Kg during the study spam according to baseline TSH levels

		e-LT4 (at recruitment) (A)	ef-LT4 (after 6 months) (B)	ef-LT4 (after 12 months) (C)	p
N		31	31	31	A vs. B vs. C	A vs. B	A vs. C	B vs. C
LT4 dosage/kg	TSH ≤ 2.5 mIU/ml N = 15	1.3 ± 0.2	1.3 ± 0.2	1.3 ± 0.3	0.754	0.719	0.682	0.813
LT4 dosage/kg	TSH > 2.5 mIU/ml N = 16	1.3 ± 0.3	1.3 ± 0.3	1.3 ± 0.4	0.824	0.892	0.806	0.759
TSH (mIU/ml)	TSH ≤ 2.5 mIU/ml N = 15	1.8 ± 0.4	2.0 ± 0.5	3.1 ± 1.1	< 0.001	< 0.001	< 0.001	0.004
TSH (mIU/ml)	TSH > 2.5 mIU/ml N = 16	3.2 ± 0.5	3.3 ± 0.6	3.7 ± 0.7	0.032	0.071	0.009	0.014
fT4 (ng/dl)	TSH ≤ 2.5 mIU/ml N = 15	1.3 (IQR 1.2–1.4)	1.2 (IQR 1.1–1.3)	1.2 (IQR 1.1–1.3)	0.053	0.065	0.042	0.063
fT4 (ng/dl)	TSH > 2.5 mIU/ml N = 16	1.2 (IQR 1.0–1.3)	1.1 (IQR 1.0–1.3)	1.0 (IQR 0.9–1.2)	0.034	0.032	0.021	0.047

One-way repeated measures ANOVA and Bonferroni post-hoc test or Friedman and Dunns post-hoc tests as appropriated

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