Table 2 Results of systematic reviews
From: Comparing antithyroid drugs vs. radioactive iodine in paediatric Graves’ disease: literature review
Study Reference | Number of Study Participants | Cohort Studies included | RCTs included | Overall Findings |
|---|---|---|---|---|
Lutterman et al. [24] 2021 | 1,283 | 23 | 0 | Treating patients with 11-15MBq iodine-131 per gram of thyroid tissue is an effective treatment option when aiming to achieve hypothyroidism. Efficacy seems to increase with dosage and activity of RAI. Short-term & long-term side effects are a rare occurrence in radioactive iodine treatment. |
JM van Lieshout et al. [25] 2021 | 3,057 | 24 | 5 | Intention to treat analysis (ITTA) showed an overall remission rate of 28.8% in methimazole treated patients. Going up to 75% as treatment duration rises to 9 years • Occurrence of adverse effects: 17.6% • Occurrence of major side effects: 1.1%• |